Empowering your research with mRNA technology
Application
At the inception of mRNA therapeutic design, wemust first define our objective-the disease to betreated or the health condition to be improved.Through rigorous research and data analysis, weidentify the protein that needs to be encoded.
Protein
Subsequently, we select the target protein.This involves recognizing proteins associatedwith the disease and understandingtheir structure and function.
MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
Protein Sequence Optimization
We then optimize the selected protein sequence toensure its stability and functionality within thehuman body. Using computational simulations andbioinformatics tools, we can predict and improvethe protein's structure for enhanced efficacy.
AUGUUCGUGUUUUUGGUUCUGCUACCACUUGUUUCAUCCCAGUGCGUGAACCUUACAACACGGACGCAGUUGCCGCCUGCGUACACUAAUUCAUUCACGCGAGGGGUGUAUUACCCGGACAAGGUGUUUCGUUCGUCGGUGCUUCACUCCACGCAAGACCUAUUCCUGCCAUUUUUCUCUAAUGUCACGUGGUUUCACGCGAUUCAUGUGAGUGGCACGAAUGGCACUAAACGUUUCGACAACCCGGUAUUACCGUUUAAUGACGGGGUGUACUUCGCCUCGACAGAGAAAUCAAAUAUCAUUAGAGGCUGGAUCUUUGGCACAACACUAGACUCUAAGACGCAAAGCUUGCUUAUUGUAAAUAAUGCUACCAAUGUCGUUAUCAAAGUAUGUGAAUUUCAAUUCUGCAAUGACCCGUUCCUUGGGGUAUAUUAUCAUAAAAAUAAUAAGUCUUGGAUGGAGAGUGAGUUUAGAGUCUAUUCGUCGGCAAACAAUUGUACUUUUGAGUACGUUUCACAACCUUUCUUAAUGGAUCUGGAGGGCAAACAAGGGAAUUUCAAGAACUUGAGGGAGUUUGUGUUCAAGAAUAUUGAUGGCUACUUCAAAAUUUACAGUAAACACACACCGAUUAAUUUAGUACGUGAUCUACCCCAGGGGUUUUCCGCCCUCGAGCCACUCGUGGACCUUCCUAUUGGAAUCAAUAUAACCCGGUUCCAGACAUUGUUAGCCCUUCAUAGGAGCUAUUUAACUCCAGGAGACAGCUCUUCGGGCUGGACAGCGGGAGCGGCAGCGUAUUACGUCGGCUAUUUGCAGCCCCGUACCUUUCUAUUAAAGUACAAUGAGAAUGGCACUAUUACGGAUGCGGUUGAUUGCGCUCUGGACCCCUUGUCCGAAACAAAGUGUACCCUCAAGUCGUUCACUGUCGAAAAGGGCAUCUAUCAGACGAGUAAUUUCCGUGUACAACCGACGGAGUCGAUAGUUCGCUUUCCAAAUAUUACCAAUCUUUGUCCAUUCGGCGAGGUCUUUAACGCAACUCGAUUCGCUUCCGUUUACGCCUGGAACCGGAAACGGAUAAGCAACUGUGUGGCGGACUAUAGCGUCCUGUACAAUUCUGCGAGCUUCUCAACAUUUAAGUGUUAUGGAGUGAGCCCCACUAAAUUGAAUGACCUCUGCUUCACCAAUGUCUAUGCGGACUCCUUUGUAAUCCGGGGUGAUGAGGUACGACAAAUUGCACCCGGCCAGACGGGGAAAAUCGCUGAUUACAAUUAUAAGCUACCGGACGACUUUACCGGCUGCGUAAUAGCGUGGAACUCUAACAACCUCGAUUCUAAGGUGGGUGGGAACUACAACUAUCUGUACAGGCUAUUUCGAAAAUCUAAUCUUAAGCCUUUUGAACGCGAUAUUUCAACUGAAAUUUAUCAGGCCGGGUCAACGCCUUGCAACGGGGUGGAGGGGUUUAAUUGCUAUUUCCCGUUGCAAUCCUACGGCUUUCAGCCGACAAACGGAGUAGGAUACCAACCGUACCGAGUAGUAGUAUUAUCCUUCGAACUUUUACACGCACCGGCGACCGUUUGCGGUCCAAAGAAGUCUACUAAUCUAGUAAAAAACAAAUGUGUUAAUUUCAACUUUAACGGGUUGACUGGCACAGGCGUUCUGACUGAGUCUAACAAAAAGUUCCUGCCGUUUCAACAAUUUGGUAGAGAUAUAGCGGACACCACUGAUGCAGUAAGAGAUCCCCAAACGCUGGAAAUUCUAGACAUCACACCCUGUUCCUUUGGAGGUGUCUCUGUGAUCACUCCCGGGACUAAUACCAGCAAUCAAGUCGCGGUUCUCUACCAGGAUGUCAACUGUACAGAGGUACCGGUAGCAAUCCAUGCUGAUCAGCUAACGCCGACUUGGAGAGUCUACAGCACCGGAUCUAACGUUUUUCAGACGCGGGCUGGGUGUCUAAUAGGCGCGGAGCACGUAAACAAUUCAUAUGAGUGUGAUAUACCCAUCGGUGCCGGGAUCUGCGCUUCAUACCAGACACAAACUAAUAGCCCAAGGCGCGCUCGAUCCGUGGCUAGUCAGAGUAUUAUAGCUUAUACGAUGUCCUUAGGAGCAGAGAAUUCUGUCGCCUAUAGUAACAAUUCAAUUGCUAUCCCUACCAAUUUCACGAUCUCUGUUACUACCGAGAUUUUACCAGUUAGCAUGACCAAAACGAGCGUGGAUUGUACAAUGUAUAUUUGUGGAGACAGCACAGAAUGUUCGAAUCUACUGCUACAGUAUGGCAGUUUUUGCACACAAUUAAAUAGAGCGCUGACAGGCAUUGCCGUGGAACAGGAUAAAAAUACCCAGGAAGUCUUCGCACAAGUAAAGCAAAUUUACAAAACCCCGCCGAUCAAAGAUUUUGGCGGGUUUAAUUUCUCACAGAUACUGCCCGAUCCUAGUAAGCCCAGCAAACGUAGUUUCAUAGAAGACUUGCUCUUCAACAAAGUAACGUUGGCAGAUGCAGGAUUUAUUAAACAAUAUGGUGACUGUCUAGGGGACAUUGCAGCGCGCGAUUUAAUUUGUGCGCAAAAAUUCAACGGACUCACGGUGCUGCCGCCCUUAUUGACGGACGAGAUGAUAGCGCAAUAUACGUCAGCACUCUUGGCGGGGACCAUAACCUCGGGCUGGACCUUCGGCGCCGGAGCCGCGUUGCAGAUACCAUUUGCUAUGCAAAUGGCGUAUAGAUUCAACGGAAUCGGGGUAACUCAAAACGUUCUUUAUGAAAACCAGAAACUGAUCGCCAACCAGUUCAAUAGCGCCAUUGGCAAAAUACAAGACAGCUUGUCAUCAACAGCCUCUGCACUGGGUAAAUUACAGGAUGUUGUAAACCAGAAUGCGCAAGCUUUAAACACUCUUGUGAAACAACUCUCGUCAAAUUUCGGGGCUAUCAGCUCUGUGCUCAAUGACAUACUCUCGAGACUUGAUAAGGUGGAGGCAGAAGUACAAAUUGAUAGGCUGAUUACUGGUCGUCUCCAAUCCCUUCAAACUUAUGUUACUCAGCAACUGAUCAGAGCAGCUGAGAUUCGUGCAUCGGCGAACCUGGCAGCUACUAAGAUGUCAGAGUGCGUCUUAGGCCAGUCAAAGCGGGUGGACUUCUGUGGGAAAGGCUACCACCUCAUGUCAUUCCCCCAGUCAGCUCCACAUGGCGUGGUUUUCUUACAUGUGACGUACGUUCCAGCGCAGGAGAAAAAUUUCACAACAGCUCCAGCCAUAUGUCAUGAUGGUAAGGCGCACUUCCCUCGGGAAGGCGUCUUUGUCUCUAACGGCACUCAUUGGUUUGUGACCCAGCGCAAUUUUUAUGAACCUCAAAUAAUAACAACGGAUAACACGUUCGUGAGCGGAAAUUGUGAUGUGGUGAUCGGCAUAGUGAACAACACAGUAUACGACCCUCUCCAACCGGAACUCGAUUCCUUCAAAGAAGAACUUGACAAAUACUUUAAAAACCAUACCUCCCCAGAUGUAGACCUUGGUGACAUAUCUGGUAUUAAUGCAUCCGUGGUUAACAUACAGAAAGAAAUAGAUCGACUUAACGAGGUGGCUAAGAACUUAAACGAAUCCCUCAUCGACCUCCAAGAGUUAGGAAAGUACGAACAGUACAUCAAGUGGCCAUGGUAUAUUUGGUUAGGAUUCAUCGCUGGACUCAUAGCUAUCGUUAUGGUGACAAUAAUGCUGUGCUGCAUGACGUCGUGUUGUUCUUGCUUAAAGGGAUGUUGUUCCUGCGGUUCUUGUUGCAAAUUUGAUGAGGACGACUCAGAGCCCGUGCUUAAGGGCGUUAAGCUGCAUUACACGUAG
mRNA Sequence Optimization
To ensure stability and efficient translation ofmRNA within the body, we optimize various components of the mRNA sequence. This includes the 5' Cap, the 5' Untranslated Region (5' UTR), the Coding Sequence (CDS), the 3' Untranslated Region (3' UTR), and the PolyA tail.
mRNA Manufacture
The optimized mRNA sequence is synthesized inthe laboratory. This process demands high-precision instruments and stringent quality controlmeasures to ensure the production of mRNA withhigh purity and activity.
Encapsulation
To protect the mRNA and facilitate its entry intocells, we encapsulate it in lipid nanoparticles(LNPs). These nanoparticles effectively evadedetection by the immune system and safely deliverthe mRNA to target cells.
mRNA Released
Once inside the cell, the encapsulated mRNA isreleased into the cytoplasm. Here, the cellulartranslational machinery commences, convertingthe mRNA into the target protein. This step iscritical for the therapeutic action of mRNA drugs.
Protein Functions
Ultimately, the translated protein begins exertingits biological functions within the cell. Whetherrepairing damaged cells, modulating immuneresponses, or inhibiting pathogen proliferation,these proteins work towards achieving therapeuticeffects and enhancing patient health.